Acquired deficiency of A20 results in rapid apoptosis, systemic inflammation, and abnormal hematopoietic stem cell function

Acquired deficiency of A20 results in rapid apoptosis, systemic inflammation, and abnormal hematopoietic stem cell function

A20 is a damaging regulator of NF-κB, and mutational loss of A20 expression is concerned in the pathogenesis of autoimmune illnesses and B-cell lymphomas. To make clear the function of A20 in grownup hematopoiesis, we generated conditional A20 knockout mice (A20(flox/flox) ) and crossed them with Mx-1Cre (MxCre (+)) and ERT2Cre (ERT2Cre (+)) transgenic mice …

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