Acquired deficiency of A20 results in rapid apoptosis, systemic inflammation, and abnormal hematopoietic stem cell function
A20 is a damaging regulator of NF-κB, and mutational loss of A20 expression is concerned in the pathogenesis of autoimmune illnesses and B-cell lymphomas. To make clear the function of A20 in grownup hematopoiesis, we generated conditional A20 knockout mice (A20(flox/flox) ) and crossed them with Mx-1Cre (MxCre (+)) and ERT2Cre (ERT2Cre (+)) transgenic mice …